你非走不可真是件憾事。

It's a pity that you should have to leave.

你要是不品尝一下就走，那将是一大憾事。

It would be a pity if you left without tasting it.

本人因工作忙和自家家务事未处理好，爷爷、奶奶临终未能再看一眼，乃余终生憾事。

It's a pity of my life to be unable to see my paternal grandparents on their deathbed since I was plagued by heavy work and burdened with onerous household at that time.

这是件憾事, 因为减少噪音实在是一项美好的事业; 如果把它与贫乏的科学知识搅在一起,那么这种美好的事业有可能使人生疑.

This is a pity, because noise abatement really is a good cause, and it is likely to be discredited if it gets to be associated with bad science.

他们没有更出名，真是件憾事。

It is a shame that they are not better known.

棍棍：“那第一大憾事是啥？”

So what's the first worst thing?

当今社会无用信息如此之少，实为憾事。

It is a very sad thing that nowadays there is so little useless information.

谁不知道闻名遐迩忍者神龟的是童年的一大憾事.

Who does not know well - known a turtle.

我过去没有做的善事， 已经成为无法更正的憾事。

For whatever good I have failed to do is irretrievably past.

在此先引义律上校一八三九年九月五日信中所曰之憾事。

He would first refer to the unfortunate transaction mentioned in Captain Elliot's letter of the 5th of September, 1839.