OBJECTIVE:To increase the accuracy of blood concentration monitoring results of tacrolimus.

目的：提高他克莫司血药浓度监测结果的准确性。

OBJECTIVE: To increase the accuracy of blood concentration monitoring results of tacrolimus.

目的：提高他克莫司血药浓度监测结果的准确性。

Objective To observe the effectiveness of Tacrolimus Ointment on corticosteroid-dependent dermitis.

目的：观察他克莫司软膏对激素依赖性皮炎的治疗作用。

Objective To observe the effectiveness of Tacrolimus Ointment on corticosteroid - dependent dermitis.

目的:观察他克莫司软膏对激素依赖性皮炎的治疗作用.

RESULTS The solubility and in vitro dissolution of all tacrolimus solid dispersions were increased significantly.

结果各种固体分散体均能大大增加他克莫司的溶解度，加快其体外溶出。

Carcinogenicity studies conducted with topical application of tacrolimus in mice demonstrated a dose - dependent development of lymphoma.

在老鼠上进行的tacrolimus致癌动力研究表明了剂量和淋巴瘤的依赖关系.

The bioavailability and metabolism of cyclosporine A and tacrolimus are primarily controlled by transport protein and cytochrome P450 isoenzyme system.

环孢素A和他克莫司的生物利用度和代谢主要受转运蛋白和细胞色素P450同工酶系统影响。

In the 2-week induction phase, patients received topical tacrolimus every morning and a strong- or weak-potency corticosteroid ointment in the evening.

在为期两周的诱导期内，患者每天早晨外用他可莫斯，晚上外用强效或弱效激素类药膏。

In conclusion, early steroid withdrawal after LT is feasible under tacrolimus monotherapy without increased rejection rates and with a lower rate of side effects.

综上所述，早期肝移植后类固醇撤退并使用他克莫司治疗，没有增加排斥反应的发生率，并且副作用发生率也低。

CONCLUSION The effects of PVP and HPMC as carriers of solid dispersions to increase the solubility and in vitro dissolution of tacrolimus solid dispersions are better than F68 and S40.

结论PVP或HPMC作为载体制成固体分散体，对增加他克莫司的溶解度和体外溶出度的效果优于F68和S40。