The project faced a major setback due to funding issues.

由于资金问题，项目面临重大挫折。

First, has the candidate faced a crisis or overcome a major setback in his or her life?

首先，这位候选人一生中有没有遇到过危机呢? 或者有没有克服过人生的重大挫折呢？

The major setback to this static multiple access scheme is the fact that the different users see the wireless channel differently is not being utilized.

这种静态多路访问方案的主要缺点在于，不同用户使用无线信道的时段不同这一事实没有得到利用。