I am so sorry I screwed up.

对不起，我把事情搞砸了。

E. g. Look, I know I screwed up.

我知道我把事情搞砸了。

I screwed up my project. I feel really frustrated.

我把这个项目搞砸了。我真的感觉很沮丧。

I screwed up the jar and put it back on the shelf.

我把罐子拧上盖儿，放回搁架。

He gave me a place in this crappy world, until I screwed up.

他让我在这个糟透了的世界上得以生存下去，直到我搞砸了。

I'm particularly troubled that what NASA's doing right now with this new Bush doctrine to -- for this next decade and a half -- oh shoot, I screwed up.

我特别担心，美国国家宇航局现在根据新的布什政府的原则所做的--因为在未来十五年--哦 天呢，我错了。