Lo said that while his team was studying resistance, they expected to find secondary mutations in BRAF.

Lo说，虽然他的团队在研究耐药性，但是他们却希望存在BRAF的二次变异。

Mutational activation of the BRAF oncogene is the most common genetic alteration in cutaneous melanoma.

BRAF癌基因突变的激活是皮肤黑色素瘤最常见的基因改变。

About half of all melanoma patients have a mutated BRAF gene. This mutation tells the cell to continue to grow.

将近半数的黑色素瘤患者都有BRAF基因突变，从而导致黑色素肿瘤细胞继续生长。

Patients found to be positive for mutations are strongly encouraged to have surgery, using BRAF-status as a guide.

通过应用BRAF基因状态作为指导，如果发现突变阳性，则强烈建议其手术。

KRAS codon 12 and 13 mutations in relation to disease-free survival in BRAF-wild type stage III colon cancers from an adjuvant chemotherapy trial (N0147 Alliance).

【译】KRAS基因密码子12和13与无病生存的野生型BRAF的II I期结肠癌辅助化疗试验从一个突变(n0147联盟)。

BRAF and KRAS mutant traditional serrated adenomas are morphologically related but biologically disparate polyps with distinctive clinicopathological and molecular features.

BRAF和KRAS突变传统锯齿状腺瘤为形态学相关、但生物学上不同的息肉，具有不同的临床病理学和分子特征。

In a clinical trial at UCLA's Jonsson Cancer Center and other locations, patients with BRAF-mutated metastatic melanoma have been responding very well to an experimental drug, PLX4032.

在UCLA琼森癌症研究中心和其他地方的临床试验中，一种试验药物，PLX4021，对BRAF基因变异的黑素瘤转移病人的效果很好。