Tobacco increased significantly the mutation rate of Salmonella typhia and the formation rate of CHO colony.

烟草能显著地提高伤寒沙门氏菌突变率和CHO细胞集落形成率；

As atypical typhia is increasing in clinical practice, the cases of typhia which mainly show complications are easily misdiagnosed, and even lead to severe consequences.

鉴于伤寒临床表现的不典型病例增多，以并发症为主要表现的病例更易导致误诊，甚至引起不良后果。