Some common signs and symptoms of depression include feelings of hopelessness, pessimism, worthlessness, and helplessness.

一些常见的忧郁迹象和症状，包括感到绝望、思想悲观，或者觉得失去价值、徬徨无助。

This habit can worsen the symptoms at night leading to difficulty in falling asleep, feelings of hopelessness, anxiety and isolation.

这个习惯会使夜间的症状恶化，导致失眠、绝望感、焦虑和孤独。

This method must not however lead to premature confrontation with the demands and stresses of working life or, nor to feelings of hopelessness in the face of human brutality and greed.

这种方法不应该导致过早地对劳动生活的要求和压力产生对抗，也不应导致在面对人类的残暴和贪婪之下形成无望的情绪。