Objective To study the side effects of thalidomide in treating malignant plasmacyte disease.

目的进一步认识反应停在治疗恶性浆细胞疾病时可能出现的不良反应。

Multiple myeloma is a vicious monoclonal B - cell disease with plasmacyte proliferating slowly.

多发性骨髓瘤是一种浆细胞恶性增生，单克隆免疫球蛋白合成异常的恶性疾病。

Conclusion: Proliferation of bone marrow plasmacyte and the quantity or urine Bence-Jones protein are main causes of kidney lesion in multiple myeloma.

结论：骨髓浆细胞增殖及尿链蛋白产生可能是多发性骨髓瘤肾脏损害的主要原因。

Methods the rare side effects of thalidomide in treating 4 cases of malignant plasmacyte disease were investigated and the pertinent literatures were reviewed.

方法总结应用反应停治疗恶性浆细胞疾病时见到的4例罕见不良反应的患者，并进行相关文献复习。

There was no significant difference of the incidence of lymphocyte hyperplasia, lymphoid follicular formation, eosinophil and plasmacyte infiltration between the groups.

淋巴细胞增生、淋巴滤泡形成、嗜酸性粒细胞和浆细胞浸润，三组间差异均无显著性。