Fluids may increase intra-erythrocyte free water and hinder the formation of sickling.

液体治疗可使红细胞内自由水增加，从而阻止镰状变形。

With the removal of oxygen from sickle hemoglobin, the red blood cell deforms into a sickled shape. This sickling damages the RBC membrane and increases the likelihood of rupture and anemia.

随着镰珠蛋白中氧的去除，红细胞变形成镰状，红细胞膜受到破坏，破裂的可能性增加，从而导致贫血。