Objective To study the prophylactic effect of high dose methylprednisolone in rat acute spinal cord injury.

目的:研究大剂量甲基强的松龙对急性脊髓损伤大鼠神经功能的预防保护作用.

Summary of Background Data. High dose methylprednisolone sodium succinate (MPSS) for the patients with acute spinal cord injury has been considered standard treatment in the several countries.

急性脊髓损伤时应用大剂量甲基强的松龙治疗在一些国家一直被认为是标准治疗。

Conclusion The administration of methylprednisolone or MK-801 alone or in combination has not different efficacy obviously existing experiment condition for the treatment of acute spinal cord injury.

结论甲基强的松龙、MK-801及两药联合对大鼠急性脊髓损伤的治疗作用在目前的实验条件下无明显差异。