What's the matter with you, Tony?

托尼，你怎么了？

What's the matter with you?

你怎么了？

What's the matter with you？

你怎么啦？

What's the matter with you?

你怎么了？

What's the matter with you this morning?

今天上午你怎么啦?。

What's the matter with you? you look flushed.

发生什么事了？你好像脸红了。

A:What's the matter with you ?You look angry.

你看上去很生气，怎么啦？

What's the matter with you, why don't you answer?

你怎么回事，怎么不回答？

What's the matter with you? You look apathetic today.

你怎么了？今天看起来没什么精神。

Eg2: You are acting strangely. What's the matter with you?

你最近怎么行为怪怪的，出什么事了吗？