PS 341 is a potent and selective inhibitor of the proteasome.

PS 341是蛋白酶体有效的选择性抑制药。

EIN3 is regulated by a proteasome-mediated protein degradation pathway.

EIN3受到蛋白酶体介导的蛋白降解途径的调节。

Bortezonib (velcade) is the first proteasome inhibitor that has entered clinical trial.

波替单抗(万珂)是第一个进入临床试验的蛋白酶体抑制剂。

Proteasome inhibitors can selectively promote the apoptosis of tumor cells and overcome MDR.

蛋白酶体抑制剂可选择性地促进肿瘤细胞凋亡，逆转多药耐药。

Pharmacodynamic assay has shown that inhibition of proteasome is dose dependent and reversible.

药效学分析表明蛋白酶体抑制药的抑制作用有剂量依赖性和可逆性。

Components in charge of this process include ubiquitin, its startup enzymes, and proteasome system.

负责执行这个调控过程的组成成分包括泛素及其启动酶系统和蛋白酶体系统。

Inhibition of proteasome has been emerging as a promising approach in pathway-directed cancer therapy.

蛋白酶体的抑制在肿瘤的信号通路定向治疗方面已经成为一个极其有希望的途径。

Objective To determine the influence of ubiquitin-proteasome in regulating the TRAIL-mediated apoptosis.

目的：探讨泛肽蛋白酶体对TRAIL诱导细胞凋亡作用的影响。

Ubiquitin is a conserved polypeptide unit that plays an important role in the ubiquitin-proteasome pathway.

泛素是一种保守的多肽单元，在泛素蛋白酶体途径中起重要作用。

Objective To isolate and purify 20S proteasome from normal rat spleen and observe its morphologic features.

目的分离纯化正常大鼠脾脏2 0S蛋白酶体，并观察其形态特征。

Eukaryotic cells use autophagy and the ubiquitin-proteasome system as their major protein degradation pathways.

真核细胞使用自噬和泛素蛋白酶体系统，作为它们主要的蛋白质降解通道。

The ubiquitin-proteasome pathway is now considered as one of the most common regulatory processes in all eukaryotes.

泛素蛋白酶体途径是真核生物最普遍的调控过程之一。

The proteasome is an abundant, catalytic complex that is found in both the nucleus and cytoplasm of eukaryotic cells.

蛋白酶体是存在与真核细胞的细胞核和细胞质中的含量丰富且有催化作用的复合物。

The proteasome inhibitor MG-132 can reduce the lung injury induced by hyperoxia and inhibit P38MAPK signaling pathway.

蛋白酶体抑制剂MG - 132可以减轻高氧引起的肺损伤，可能对p 38 MAPK信号通路有抑制作用。

AIM: to investigate effects of ubiquitin-proteasome inhibitor on proliferation and apoptosis of gastric carcinoma cells.

目的：研究泛素蛋白酶体抑制剂对胃癌细胞增殖和凋亡的影响。

Objective to explore the effects of proteasome inhibitor MG-132 on proliferation, apoptosis of U87 glioma cells in vitro.

目的探讨蛋白酶体抑制剂MG - 132对体外人u87胶质瘤细胞增殖和凋亡的影响。

The expression of MHC I molecules on the muscle cells can be inhibited by the proteasome inhibitors lactacystin and MG132.

用蛋白酶体抑制剂抑制可以明显阻断肌细胞MHC I分子的表达；

Studies suggest that, in sepsis, skeletal muscle protein catabolism and the ubiquitin-proteasome system are closely related.

研究认为脓毒症大鼠骨骼肌蛋白高分解代谢与泛素-蛋白酶系统密切相关。

The special characteristics of CHIP make it become the bridge of molecular chaperone system and ubiquitin-proteasome pathway.

CHIP的特殊结构特征使其成为沟通分子伴侣与泛素-蛋白酶体通路之间的桥梁，是蛋白质量控制系统的重要中介分子。

The ubiquitin / proteasome system plays an important role in plant growth and development, morphogenesis and disease resistance.

泛素/蛋白酶体系统在植物的生长发育、形态建成和抗病反应等过程中起着重要的作用。

Objective To study the formation and development of inclusions in dopaminergic PC12 cells treated with proteasome inhibitor PSI.

目的研究蛋白酶体抑制剂PSI诱导PC12细胞胞浆内嗜酸性包涵体的形成及演变过程。

Furthermore, the effect of proteasome inhibitors and TAP on particle antigens cross presentation was investigated by FACS analysis.

进而，采用流式细胞技术研究了不同蛋白酶体抑制剂以及TAP对噬菌体颗粒抗原交叉呈递的影响。

This review summarizes composition and structure of proteasome, its physiological and pathological actions, and available inhibitors.

本文对蛋白酶体的组成结构、病理生理作用和现有抑制剂进行归纳总结。

This paper reviews the biological functions of proteasome in signal transduction and its potential roles in neurodegenerative diseases.

本文综述蛋白酶体在细胞信号转导中的生物学功能和在神经退行性疾病中的可能作用。

Recent studies have shown that some pathogens can mimic the host plant ubiquitin / proteasome system components to achieve their own purposes.

近年的研究表明，某些病原菌能够模拟寄主植物泛素/蛋白酶体系统组分，从而达到利用该系统为病原菌服务的目的。

We are studying the underlying mechanisms of leaf polarity formation regulated by 107 gene and the relationship between 107 and 26s proteasome.

我们正在分析107基因调控叶的极性建成的分子机理及其与26s蛋白酶体之间的关系。

The proteasome is an abundant multi-enzyme complex that provides the main pathway for degradation of intracellular proteins in eukaryotic cells.

蛋白酶体是真核细胞中含量丰富的多酶复合物，它主要协助降解细胞内的蛋白。

Protein degradation mediated by ubiquitin-proteasome pathway is an important mechanism which modulates cellular proteins′ activity and function.

泛素- 蛋白酶体途径介导的蛋白降解是机体调节细胞内蛋白水平与功能的一个重要机制。

The ubiquitin-proteasome proteolytic pathway, a major pathway for protein degradation in cells, plays a critical role in the protein metabolism.

泛素介导的蛋白质降解途径是降解细胞内蛋白质的主要途径， 在维持细胞正常的蛋白质代谢中起着至关重要的作用。

In addition, following chemotherapy, there was a significant decrease in proteasome levels in patients who responded compared to those who did not.

此外，对化疗有反应的患者在治疗后蛋白酶体水平有显著的降低。