OPG-RANKL-RANK signal pathway is a milestone in the history of bone biological.

OPG-RANKL-RANK系统是骨生物学史上的重要里程碑式发现。

Partial mechanism of DGRBOS in treating osteoporosis might be promoting osteoblast proliferation and regulating OPG/RANKL expression.

阿胶强骨口服液治疗骨质疏松疗效机制之一可能与其促进成骨细胞的增殖，调节OPG/RANKL表达有关。

Objective To determine whether leukotriene B4 (LTB4) could directly stimulate human osteoclast differentiation and activation independent of RANKL (ODF).

目的探讨白三烯（LT）B4能否不依赖细胞核因子资B受体激活剂配体（RANKL）直接促进人破骨细胞的分化和激活。

The influence of the heat for the relationship of osteoblast and osteoclast and the regulatory mechanism of HSP70 and HSF2 for the RANKL of osteoblast has been not interpreted thoroughly.

但目前尚未阐明热对成骨细胞与破骨细胞偶联关系的影响及热休克蛋白70（HSP70）和热休克因子2（HSF2）对成骨细胞RANKL的调节机制。

Immunohistochemical staining revealed that expression of RANKL and OPG protein was detected in osteoblasts, bone lining cells, fibroblasts and osteoclasts which mostly located in resorption lacunae.

免疫组化结果显示，RANKL和OPG的阳性表达位于牙周成骨细胞、骨衬里细胞、牙周纤维细胞和位于骨陷窝内的破骨细胞中。