He persisted in disregard of all difficulties.

尽管困难重重，但他还是坚持了下来。

This is a highly irresponsible and unfounded accusation in disregard of the facts.

欧洲议会罔顾事实，妄加评论，无端指责，极不负责。

Secondly, Nietzsche thinks the asceticism is in disregard of human life. for your reference~~.

其次，尼采认为禁欲主义是对人的生命的漠视；

Deliberately intercepting or boarding vehicles by force or impeding the normal operation of vehicles in disregard of dissuasion;

无理拦截车辆或者强行登车影响车辆正常运行，不听劝阻的；