随着病情的发展，大脑中堆积了越来越多的脂质斑块和蛋白质脂肪纤维团，神经细胞被其团团围住，并最终被破坏致死。

As the disease progresses, fatty plaques and fibrous tangles of protein build up in the brain, ensnaring nerve cells and eventually strangling them to death.