吴冠中是20世纪后期中国画坛无法忽略也无可代替的人物。

In Chinese painting circles in the later stage of the 20th century, Wu is a non-negligible and irreplaceable figure.

工作是无可代替的；无论是甜蜜的爱情，还是健康的身体，都不能取工作而代之。

There can be no substitute for work; neither affection nor physical well-being can replace it.