导致

lead to; cause; eventuate; induce; bring; prompt; beget; occasion; give rise to; bring about; make for; result in; productive; downstream; conducive; contributory

彻底的

hundred-percent; thoroughgoing; exhaustive; thorough-paced; dyed-in-the-wool; thorough

疏远

alienate; loosen; distance; estrange; aloof; remote; distant; estranged; alienated; distantly; disfavour; alienation; estrangement