On the other hand, he said, "These men are irremediably lost."

另一方面他又说：“这些人都是不可救药的。”

Although remorse is usually thought to spring from regret for having done something wrong, it may be that its origin is the realization that one's own nature is irremediably flawed.

尽管懊悔通常被认为源自于一个人对做错事情的悔恨，但其原因可能是一个人意识到自身存在的无可救药的缺陷。