Perhaps the biggest downside on Young is one of his upsides-his running ability.

或许最大的坏处是他对年轻按惯例-其运行能力。

While there are cost benefits to this approach the biggest downside is the restriction of future upgrade options.

这种方法在降低成本的同时，最多的缺点就是对未来升级的限制。

The biggest downside to the JiBX binding approach, at least in web service terms, is probably that JiBX currently provides weak support for working from an XML schema definition.

JiBX 绑定方法最大的缺陷（至少从 Web 服务方面可以这样说）可能就是，JiBX 目前对从 XML 模式定义工作的支持非常微弱。

Like DNA sequencing, fiber-optic systems provide data for months after installation, if the fiber remains intact, but their biggest downside is cost.

和DNA测序一样，光纤系统安装完毕后，在设备完好的情况下可以几个月持续性传输数据，但是最大的缺点是成本高。