Performing de novo sequencing without knowing amino acid masses is very novel.

在不知道氨基酸团块的情况下进行从头测序是很新奇的。

It was demonstrated that the increase is due to de novo synthesis of fresh enzyme.

结果表明，酶活性的增加是由新酶的从头合成引起的。

In the end, the researchers obtained 40x genome coverage and generated a high-quality draft assembly using the 454 GS De Novo Assembler Software (Newbler).

最终，研究人员获得 40 倍的基因组的覆盖面和运用 454 GS 的 De Novo 序列拼接软件（Newbler）绘制出了高质量的草图。

Because Schinzel-Giedion was already thought to be caused by a DE novo, dominant mutation, narrowing down the list of candidate genes was slightly different than for inherited, recessive disorders.

由于Schinzel - Giedion早已被认为是由新生显性突变引起的，因此缩小候选基因的列表就与隐性遗传疾病略有不同。