Staging Liver Fibrosis: Time to Abandon Liver Biopsy?

肝纤维化的分期：是该抛弃肝脏活检的时候了？

The change of histopathology by liver biopsy was observed simultaneously.

同时经皮肝活检观察治疗前后肝脏组织病理学变化。

The diagnosis is base on detection of virus and liver biopsy except liver function tests.

临床诊断除常规检测肝功能外，主要依靠病毒学检测及病理诊断。

There was no influence of fibrosis stage on liver biopsy in the insulin-resistance development.

在胰岛素抵抗的患者中经肝穿刺检查对纤维化无显著影响。

Though liver biopsy is the gold standard, it is difficult to be popularized because of its trauma.

肝组织活检是金标准，但是因其创伤性等难以推广。

The study analyzed DNA samples from 236 white female patients with NAFLD confirmed by liver biopsy.

本研究分析了236例经肝活检确证的NAFLD女性患者的DNA样本。

During a liver biopsy, a small sample of liver tissue is collected and examined under the microscope.

肝活检就是取一小块肝组织在显微镜下检查。

Nonetheless a major problem is that liver biopsy itself has significant variability for fibrosis assessment.

尽管如此，一个重大问题是肝组织活检本身对纤维化评估具有变异性。

Liver biopsy is the gold standard for hepatic fibrosis diagnosis, however, it is invasive and has limitations.

肝活检是诊断肝纤维化的金标准，但其为创伤性的，且有局限性。

Methods a retrospective analysis was performed in 45 patients with IH and liver biopsy was performed in 9 patients.

方法回顾性分析45例缺血性肝炎，并对9例缺血性肝炎患者行肝穿刺组织病理检查。

Liver biopsy specimens obtained from 60 patients with severe subacute hepatitis were observed with light microscopy.

本文对60例亚重肝的肝标本进行了研究。

Among the 5 patients with upgraded diagnosis, 2 were male, 1 had drug history, 2 had positive AMA and 5 had liver biopsy.

诊断升级的5例病例中，男性2例，1例有确切用药史，2例抗线粒体抗体阳性，5例均具备病理检查结果。

Methods 303 patients with the diagnosis of CHB, the liver functions were tested and the pathological changes were shown by liver biopsy.

方法选择符合诊断标准的303例慢性乙型肝炎患者，检测血清肝功能、进行肝脏活检，肝脏组织标本进行常规病理检测。

After compound 861 treatment for 6 months, the number of activated HSC decreased and the apoptosis of HSC could be seen in the liver biopsy.

复方861治疗6个月后，活化的星状细胞数量显著减少，可观察到其凋亡。

Objective To explore the application value of percutaneous liver biopsy guided by ultrasound in infants with infant hepatitis syndrome (IHS).

目的探讨超声引导经皮肝穿活检在婴儿肝炎综合征(IHS)的应用价值。

Conclusion Non-invasive methods play important roles in diagnosis and assessing severity of liver fibrosis, and reduce the need of liver biopsy.

结论非侵人性评价方法在肝纤维化的诊断和严重程度分级方面发挥重要作用，可以在一定程度上代替组织活检。

Objective:To explore the clinical significance of liver biopsy in diagnosis and differentiated diagnosis for complication after liver transplantation.

目的：探讨经皮肝穿刺病理活检在肝移植术后并发症诊断及鉴别诊断中的意义。

We examined CD3ICD56 expression of liver lymphocytes from32 liver biopsy specimens obtained from patients with hepatitis B(RB) by two- color flow cytometry.

其次，我们运用流式细胞术检测32例乙型病毒性肝炎患者肝穿标本中淋巴细胞CD3／CD56的表达。

Like any surgery, liver biopsy does have some risks, such as puncture of the lung or gallbladder, infection, bleeding, and pain, but these complications are rare.

和其它手术一样，肝脏穿刺是有一点危险，例如：扎到肺，胆囊，感染，流血，疼痛等，但是这些事情很少很少见。

The experience in this case suggests that preoperative liver biopsy may be useful to exclude first-degree relative donors with potential PSC prior to LDLT for PSC.

这个病例的经验提示：在采用LDLT治疗PSC之前，手术前的肝组织活检或许有助于排除合并潜在性psc的一级亲属供体。

In the donor operation, the donor liver biopsy revealed expansion of the portal zone with lymphocytic infiltration and dense concentric fibrosis developed around a bile duct.

在供体手术中，供体肝组织活检显示：门脉区域扩张伴淋巴细胞浸润以及胆管周围致密向心性纤维化。

Patients and METHODS: Renal transplant patients positive for HBV surface antigen (HBsAg) and submitted to a liver biopsy because of evidence of viral replication were included.

材料和方法：对肾移植患者检测出乙肝病毒表面抗原(HBsAg)阳性者进行肝活检，由此确定病毒复制证据。

Results 17 patients were operationed , the other 7 patients underwent ultrasonically guided liver biopsy. 24 cases confirmed primary carcinoma of liver by diagnostic pathology.

结果其中17例予以手术切除、另7例进行超声引导下经皮经肝组织穿刺活检术，所有病例均经病理证实为原发性肝癌患者；

Seventy-five liver biopsy specimens taken from patients with chronic active hepatitis (CAH) were studied with light microscopy, and 22 of the 75 with electron microscopy as well.

本文对75例慢活肝肝穿材料进行光镜检查，其中22例进行透视电镜观察。

Methods Liver biopsy tissues and clinical data of 32 patients with NASH were collected and the clinicopathological findings by he and Masson staining were evaluated for NASH grading.

方法收集32例NASH的肝穿刺标本及临床资料，通过HE染色及特殊染色观察其组织学特点，并进行病理分级。

Liver biopsy remains a significant feature of studies delineating long-term outcome of NAFLD, some of which have shown that "simple steatosis" is not always non-progressive and benign.

肝活检仍然是描绘NAFLD长期结局的一个重要指标，肝活检显示为“单纯性脂肪肝”并非肯定疾病就不会进展和是良性疾病。

Objective To evaluate the diagnostic values of characteristic pathologic changes in the liver biopsy specimens, and to develop a numerical scoring diagnostic standard and coordinates system.

通过量化手段确定各种基本病理变化在肝病诊断中的价值，建立肝组织病理活动性量化诊断标准及坐标系。

Results There was good relation between quantitative ultrasonographic score and pathological liver biopsy. With the ultrasonic score increasing, the degree of liver fibrosis gradually increased.

结果超声检查评分与病理检查相关性良好，随着超声评分分值增加，肝纤维化程度也逐渐加重。