This work was mainly focused on the transcriptional regulation of human ACAT-1 gene P7 promoter activity, and the effect of fatty acids on human ACAT1 gene expression.

本论文工作着重进行人acat - 1基因P 7启动子活性调控和脂肪酸对人acat 1基因表达影响的两部分探索。

Objective: To investigate the role of taurine in acyl-coenzyme a: cholesterol acyltransferase-1 (ACAT-1) expression and activity in THP-1 and THP-1-derived macrophages.

目的：观察牛磺酸对THP - 1及THP - 1源性巨噬细胞酰基辅酶a：胆固醇酰基转移酶1 (ACAT - 1)表达及活性的影响。

Acyl-CoA: cholesterol acyltransferase(ACAT) is an intracellular enzyme that catalyzes the formation of cholesterol esters from long-chain fatty acyl coenzyme A and cholesterol.

酰基辅酶A：胆固醇酰基转移酶（ACAT）是细胞内唯一合成胆固醇酯的酶，在细胞和生物体胆固醇代谢平衡中起非常重要的作用。